{"id":5096,"date":"2025-03-26T12:55:37","date_gmt":"2025-03-26T11:55:37","guid":{"rendered":"https:\/\/schizophrenia.life\/public\/?page_id=5096"},"modified":"2025-09-16T12:42:07","modified_gmt":"2025-09-16T11:42:07","slug":"sod-chapter-1","status":"publish","type":"page","link":"https:\/\/schizophrenia.life\/public\/sod-chapter-1\/","title":{"rendered":"Chapter 1"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full square-image\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt1.jpg\" alt=\"\" class=\"wp-image-5960\" srcset=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt1.jpg 300w, https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt1-150x150.jpg 150w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"lh-n mb-2 mt-1 has-text-color has-link-color wp-elements-cb40751a74fd062134e8036e80cd4d30 wp-block-paragraph\" style=\"color:#81b39a;font-size:46px\"><strong>Chapter 1<\/strong><\/p>\n\n\n\n<p class=\"lh-n mb-2 mt-1 has-text-color has-link-color has-large-font-size wp-elements-d71d12eea83b7e6a71c9a2db2182231f wp-block-paragraph\" style=\"color:#81b39a\"><strong>Beyond coincidence:<br>When schizophrenia coexists<br>with substance use disorders<\/strong><\/p>\n\n\n\n<p class=\"mb-0 has-text-color has-link-color wp-elements-b7cd8eba13c41e6c6cbf195266b164f2 wp-block-paragraph\" style=\"color:#58595b;font-size:16px\">This chapter explores the connection between schizophrenia and substance use disorders (SUD), and the key factors behind their overlap. While challenges exist, understanding their complex relationship opens the door to better support and improved outcomes for individuals and their families.<\/p>\n\n\n\n<p class=\"has-text-align-center button__primary button-text sod-subchapter-button-81b39a wp-block-paragraph\"><a href=\"\/public\/wp-content\/uploads\/2025\/09\/01_Candid-Book-2_Chapter-1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download the chapter<\/a><\/p>\n<\/div>\n<\/div>\n\n\n<\/div><\/div><\/div><\/div><div class=\"sod_highlight py-4\"><div class=\"rea-main rea-page-default\"><div class=\"rea-page-default__wrapper my-0\"><div class=\"entry-content\">\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-578fb09b06fa0126c47f4b6bedc1ef28 wp-block-paragraph\" style=\"color:#81b39a;font-size:26px\"><strong>Fast Facts<\/strong><\/p>\n\n\n\n<p class=\"sod-border-left-81b39a mb-5 has-text-color has-link-color wp-elements-59cc9838eecc12396daf842dc9c1b52f wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#81b39a\" class=\"has-inline-color\">High prevalence of comorbidity:<\/mark><\/strong> Nearly 50% of individuals with schizophrenia also experience substance use disorders, significantly complicating recovery and emphasizing the need for integrated treatment.<\/p>\n\n\n\n<p class=\"sod-border-left-81b39a mb-5 has-text-color has-link-color wp-elements-2c463fc5f8756abd0a47a32072351ade wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#81b39a\" class=\"has-inline-color\">Complex connection:<\/mark><\/strong> The co-occurrence of schizophrenia and substance use disorders results from<br>a complex interaction of brain dysfunctions, biological risks, self-medication, and social and environmental factors.<\/p>\n\n\n\n<p class=\"sod-border-left-81b39a mb-5 has-text-color has-link-color wp-elements-711683c8b908f734094560a9b4a5f828 wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#81b39a\" class=\"has-inline-color\">Protective strategies can promote recovery:<\/mark><\/strong> Adherence to treatment, strong support networks, and integrated care are essential in managing these coexisting disorders and improving outcomes for individuals and their families.<\/p>\n\n\n<\/div><\/div><\/div><\/div><div class=\"rea-main rea-page-default\"><div class=\"rea-page-default__wrapper\"><div class=\"\"><div class=\"entry-content\">\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column sod-column sod-column-81b39a is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-1-subchapter-1\/\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/1.1.jpg\" alt=\"\" class=\"wp-image-5973\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-c0fc3766b0753d15ffc315fd40e3c1d8 wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 1.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">How are schizophrenia and substance use disorders connected?<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-81b39a is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-1-subchapter-2\/\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"213\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/1.2.jpg\" alt=\"\" class=\"wp-image-5974\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-666f6b946fde8a0ec22ce4e7167c70c9 wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 2.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Why do schizophrenia and substance use disorders overlap?<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-81b39a is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-1-subchapter-3\/\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/1.3.jpg\" alt=\"\" class=\"wp-image-5975\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-12a3514a68280dc9b4a065b8835c13dc wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 3.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Decoding addiction: key terms and their significance<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-81b39a is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-1-subchapter-4\/\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/1.4.jpg\" alt=\"\" class=\"wp-image-5976\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-8a55d440301199ef623641acd46cc15f wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 4.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">From habit to disorder: substance use and its spectrum<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-81b39a is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-1-subchapter-5\/\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/1.5.jpg\" alt=\"\" class=\"wp-image-5977\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-05aea4ac2c1a121601e93f82e0a7871b wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 5.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Healing together: protective strategies for dual disorder<\/p>\n\n\n\n<\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"custom-css-block\"><style>#aab_accordion_d0ec9df8_0 {  }<\/style><\/div><div class=\"wp-block-aab-accordion-block aab__accordion_container  accessibilityOn\" style=\"margin-top:0px;margin-bottom:15px;border:1px solid #bcb6b638\" id=\"aab_accordion_d0ec9df8_0\" role=\"button\" aria-expanded=\"false\" tabindex=\"0\"><div class=\"aab__accordion_head aab_right_icon \" style=\"background-color:#bcb6b638;border-top:none;border-right:none;border-bottom:none;border-left:none\"><div class=\"aab__accordion_heading aab_right_icon aab_right_link\"><div class=\"head_content_wrapper\"><div class=\"title_wrapper\"><h5 class=\"aab__accordion_title\" style=\"margin:0\">References<\/h5><\/div><\/div><\/div><div class=\"aab__accordion_icon\" style=\"border:0px solid transparent\"><span class=\"aab__icon dashicons dashicons-plus-alt2\" style=\"font-size:23px\"><\/span><\/div><\/div><div class=\"aab__accordion_body  \" role=\"region\" style=\"display:none;border-top:1px solid #bcb6b638;border-right:none;border-bottom:none;border-left:none\"><div class=\"aab__accordion_component\">\n<div class=\"wp-block-rea-list-rea-list-block rea-list-block front\"><div class=\"rea-list-block__wrapper\"><div class=\"list-ordered list\"><p>Black LA. Mental ill health and substance misuse: dual diagnosis [Internet]. Belfast: Northern Ireland Assembly; 2021 Mar [cited 2025 Jul 9]. Available from: <a href=\"https:\/\/www.drugsandalcohol.ie\/37356\/1\/Dual%20Diagnosis%20policy%20paper.pdf\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.drugsandalcohol.ie\/37356\/1\/Dual%20Diagnosis%20policy%20paper.pdf<\/a><\/p><p>Khokhar JY, Dwiel LL, Henricks AM, Doucette WT, Green AI. The Link between Schizophrenia and Substance Use disorder: a Unifying Hypothesis. Schizophrenia Research [Internet]. 2018;194(1):78\u201385. Available from: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6094954\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6094954\/<\/a><\/p><p>Brewer S, Godley MD, Hulvershorn LA. Treating Mental Health and Substance Use Disorders in Adolescents: What Is on the Menu? Current Psychiatry Reports. 2017 Jan;19(1).<\/p><p>Hambrecht M, H\u00e4fner H. Cannabis, Vulnerability, and the Onset of Schizophrenia: An Epidemiological Perspective. Australian &amp; New Zealand Journal of Psychiatry. 2000 Jun;34(3):468\u201375.<\/p><p>National Institute on Drug Abuse. Co-Occurring disorders and health conditions [Internet]. National Institute on Drug Abuse. 2024 [cited 2025 Jul 9]. Available from: <a href=\"https:\/\/nida.nih.gov\/research-topics\/co-occurring-disorders-health-conditions\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/nida.nih.gov\/research-topics\/co-occurring-disorders-health-conditions<\/a><\/p><p>Hjorth\u00f8j C, Compton W, Starzer M, Nordholm D, Einstein E, Erlangsen A, et al. Association between cannabis use disorder and schizophrenia stronger in young males than in females. Psychological Medicine [Internet]. 2023 May 4;53(15):1\u20137. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37140715\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37140715\/<\/a><\/p><p>Hunt A, Merola GP, Carpenter T, Jaeggi AV. Evolutionary Perspectives on Substance and Behavioural Addictions: Distinct and Shared Pathways to understanding, Prediction and Prevention. Neuroscience &amp; Biobehavioral Reviews. 2024 Feb 1;159(12).<\/p><p>Substance Abuse and Mental Health Services Administration . First-Episode Psychosis and Co-Occurring Substance Use Disorders [Internet]. Rockville, MD: National Mental Health and Substance Use Policy Laboratory; 2019 [cited 2025 Jul 10]. Available from: <a href=\"https:\/\/library.samhsa.gov\/product\/first-episode-psychosis-and-co-occurring-substance- use-disorders\/pep19-pl-guide-3\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/library.samhsa.gov\/product\/first-episode-psychosis-and-co-occurring-substance- use-disorders\/pep19-pl-guide-3<\/a><\/p><p>Cohen K, Weizman A, Weinstein A. Positive and Negative Effects of Cannabis and Cannabinoids on Health. Clinical Pharmacology &amp; Therapeutics [Internet]. 2019 Jan 31;105(5). Available from: <a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full\/10.1002\/cpt.1381\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full\/10.1002\/cpt.1381<\/a> <\/p><p>McLellan AT. Substance Misuse and Substance use Disorders: Why do they Matter in Healthcare?. Transactions of the American Clinical and Climatological Association. 2017Jun;128:112-130<\/p><p>Ward HB, Nemeroff CB, Carpenter L, Grzenda A, McDonald WM, Rodriguez CI, et al. Substance use disorders in schizophrenia: Prevalence, etiology, biomarkers, and treatment. Personalized Medicine in Psychiatry [Internet]. 2023 Jul 1;39-40(100106):100106. Available from: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2468171723000078\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2468171723000078<\/a><\/p><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Chapter 1 Beyond coincidence:When schizophrenia coexistswith substance use disorders This chapter explores the connection between schizophrenia and substance use disorders (SUD), and the key factors behind their overlap. While challenges exist, understanding their complex relationship opens the door to better support and improved outcomes for individuals and their families. Download the chapter Fast Facts High [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-sod.php","meta":{"_acf_changed":false,"rea_page_title_signed_in_meta_block_field":"","rea_page_title_signed_out_meta_block_field":"","rea_page_description_signed_in_meta_block_field":"","rea_page_description_signed_out_meta_block_field":"","rea_page_footer_id_meta_block_field":"","rea_page_footer_date_meta_block_field":"","footnotes":""},"class_list":["post-5096","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages\/5096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/comments?post=5096"}],"version-history":[{"count":1,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages\/5096\/revisions"}],"predecessor-version":[{"id":7275,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages\/5096\/revisions\/7275"}],"wp:attachment":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/media?parent=5096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}