{"id":5727,"date":"2025-04-04T06:12:07","date_gmt":"2025-04-04T05:12:07","guid":{"rendered":"https:\/\/schizophrenia.life\/public\/?page_id=5727"},"modified":"2025-04-04T06:12:07","modified_gmt":"2025-04-04T05:12:07","slug":"sod-chapter-6","status":"publish","type":"page","link":"https:\/\/schizophrenia.life\/public\/sod-chapter-6\/","title":{"rendered":"Chapter 6"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full square-image\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt6.jpg\" alt=\"\" class=\"wp-image-5964\" srcset=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt6.jpg 300w, https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/Hero_Chpt6-150x150.jpg 150w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"lh-n mb-2 mt-1 has-text-color has-link-color wp-elements-af3a3862490624c4b36325a6da27f497 wp-block-paragraph\" style=\"color:#64cef6;font-size:46px\"><strong><strong>Chapter 6<\/strong><\/strong><\/p>\n\n\n\n<p class=\"lh-n mb-2 mt-1 has-text-color has-link-color has-large-font-size wp-elements-2dffa032432585d7673b1e241e08bc4d wp-block-paragraph\" style=\"color:#64cef6\"><strong>Stimulant use in schizophrenia<\/strong><\/p>\n\n\n\n<p class=\"mb-0 has-text-color has-link-color wp-elements-43c9d8b9a9892c1557dbd7b345562c50 wp-block-paragraph\" style=\"color:#58595b;font-size:16px\">This chapter explains how psychostimulants affect the brain and body, and how to recognize the signs of stimulant use disorder, intoxication, and withdrawal among people with schizophrenia. It also discusses the challenges and possibilities in managing these dual disorders effectively.<\/p>\n\n\n\n<p class=\"has-text-align-center button__primary button-text sod-subchapter-button-64cef6 wp-block-paragraph\"><a href=\"\/public\/wp-content\/uploads\/2025\/09\/06_Candid-Book-2_Chapter-6.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download the chapter<\/a><\/p>\n<\/div>\n<\/div>\n\n\n<\/div><\/div><\/div><\/div><div class=\"sod_highlight py-4\"><div class=\"rea-main rea-page-default\"><div class=\"rea-page-default__wrapper my-0\"><div class=\"entry-content\">\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-9fbd73177ffca58e4a2552409c501ffb wp-block-paragraph\" style=\"color:#64cef6;font-size:26px\"><strong>Fast Facts<\/strong><\/p>\n\n\n\n<p class=\"sod-border-left-64cef6 mb-5 has-text-color has-link-color wp-elements-473ceac9e097bc715e5e5ba105cb5718 wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#64cef6\" class=\"has-inline-color\">Stimulants supercharge the brain.<\/mark><\/strong> Psychostimulants, like methamphetamine and cocaine, flood the brain with feel-good chemicals, boosting energy, pleasure, and alertness. But over time, they take over the brain\u2019s reward system, leading to addiction, risky behavior, and lasting mental health challenges.<\/p>\n\n\n\n<p class=\"sod-border-left-64cef6 mb-5 has-text-color has-link-color wp-elements-7684536c88404cb6a9f5daf8d49b73a0 wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#64cef6\" class=\"has-inline-color\">Stimulants and Schizophrenia.<\/mark><\/strong> For people with schizophrenia, stimulants worsen symptoms and blur the line between drug-induced psychosis and the illness itself. Treating both together is key.<\/p>\n\n\n\n<p class=\"sod-border-left-64cef6 mb-5 has-text-color has-link-color wp-elements-86daf73e14c9302998d3afeb0fe10d36 wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#64cef6\" class=\"has-inline-color\">Beyond addiction.<\/mark><\/strong> From psychosis to heart disease and even prenatal risks, stimulant use affects not just the individual but families and entire communities.<\/p>\n\n\n\n<p class=\"sod-border-left-64cef6 mb-5 has-text-color has-link-color wp-elements-2cd2b2e2965bf5dd937f1ec176421eab wp-block-paragraph\" style=\"color:#58595b\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#64cef6\" class=\"has-inline-color\">Reducing drug urges.<\/mark><\/strong> Antipsychotic medications may ease drug cravings in people with both schizophrenia and substance use disorders, offering a potential path to better treatment.<\/p>\n\n\n<\/div><\/div><\/div><\/div><div class=\"rea-main rea-page-default\"><div class=\"rea-page-default__wrapper\"><div class=\"\"><div class=\"entry-content\">\n\n\n\n<div class=\"wp-block-columns mt-7 is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column sod-column sod-column-64cef6 is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-6-subchapter-1\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/6.1.jpg\" alt=\"\" class=\"wp-image-6226\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-c0fc3766b0753d15ffc315fd40e3c1d8 wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 1.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">What is behind psychostimulants\u2019 stimulating effects?<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-64cef6 is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-6-subchapter-2\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/6.2.png\" alt=\"\" class=\"wp-image-6227\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-666f6b946fde8a0ec22ce4e7167c70c9 wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 2.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Spotting stimulant use disorder, stimulant intoxication, stimulant withdrawal: how to identify the red flags<\/p>\n\n\n\n<\/a>\n<\/div>\n\n\n\n<div class=\"wp-block-column sod-column sod-column-64cef6 is-layout-flow wp-block-column-is-layout-flow\">\n<a href=\"\/public\/sod-chapter-6-subchapter-3\">\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/schizophrenia.life\/public\/wp-content\/uploads\/2025\/09\/6.3.jpg\" alt=\"\" class=\"wp-image-6228\"\/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-12a3514a68280dc9b4a065b8835c13dc wp-block-paragraph\" style=\"font-size:16px\"><strong>Subchapter 3.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">How does stimulant use disorder impact health?<\/p>\n\n\n\n<\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"custom-css-block\"><style>#aab_accordion_bd89a544_0 {  }<\/style><\/div><div class=\"wp-block-aab-accordion-block aab__accordion_container  accessibilityOn\" style=\"margin-top:0px;margin-bottom:15px;border:1px solid #bcb6b638\" id=\"aab_accordion_bd89a544_0\" role=\"button\" aria-expanded=\"false\" tabindex=\"0\"><div class=\"aab__accordion_head aab_right_icon \" style=\"background-color:#bcb6b638;border-top:none;border-right:none;border-bottom:none;border-left:none\"><div class=\"aab__accordion_heading aab_right_icon aab_right_link\"><div class=\"head_content_wrapper\"><div class=\"title_wrapper\"><h5 class=\"aab__accordion_title\" style=\"margin:0\">References<\/h5><\/div><\/div><\/div><div class=\"aab__accordion_icon\" style=\"border:0px solid transparent\"><span class=\"aab__icon dashicons dashicons-plus-alt2\" style=\"font-size:23px\"><\/span><\/div><\/div><div class=\"aab__accordion_body  \" role=\"region\" style=\"display:none;border-top:1px solid #bcb6b638;border-right:none;border-bottom:none;border-left:none\"><div class=\"aab__accordion_component\">\n<div class=\"wp-block-rea-list-rea-list-block rea-list-block front\"><div class=\"rea-list-block__wrapper\"><div class=\"list-ordered list\"><p>Valeska Cid-Jofr\u00e9, Bahamondes T, Agustina Z\u00fa\u00f1iga Correa, Ival\u00fa Ahumada Arias, Reyes-Parada M, Renard GM. Psychostimulants and social behaviors. Frontiers in pharmacology [Internet]. 2024 Apr 25;15. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38725665\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38725665\/<\/a><\/p><p>Ramasubbu C, Poonia S, Brady-Randle E, Schutz CG, Rafizadeh R. Psychostimulant Substitution Therapy for the Treatment of Stimulant Use Disorders in Patients with Schizophrenia or Schizoaffective Disorder: A Systematic Review. Journal of Dual Diagnosis [Internet]. 2025 Mar 14;21(2):167\u201381. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40085427\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40085427\/<\/a><\/p><p>Dolan SB, Chen Z, Huang R, Gatch MB. \u201cEcstasy\u201d to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA. Neuropharmacology [Internet]. 2018 May 1;133:171\u201380. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29378213\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29378213\/<\/a><\/p><p>Stoneberg DM, Shukla RK, Magness MB. Global Methamphetamine Trends: An Evolving Problem. International Criminal Justice Review [Internet]. 2017 Oct 6;28(2):136\u201361. Available from: <a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/1057567717730104\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/journals.sagepub.com\/doi\/10.1177\/1057567717730104<\/a><\/p><p>DSM-V: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th edn). APA, 2013.<\/p><p>Ziedonis DM, Smelson D, Rosenthal RN, Batki SL, Green AI, Henry RJ, et al. Improving the Care of Individuals with Schizophrenia and Substance Use Disorders: Consensus Recommendations. Journal of Psychiatric Practice [Internet]. 2005 Sep;11(5):315\u201339. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16184072\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/16184072\/<\/a><\/p><p>Kendler KS, Ohlsson H, Sundquist J, Sundquist K. Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample. American Journal of Psychiatry [Internet]. 2019 Sep 1;176(9):711\u20139. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31055966\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31055966\/<\/a><\/p><p>Cohen-Laroque J, In\u00e8s Grangier, Perez N, Kirschner M, Kaiser S, Sab\u00e9 M. Positive and negative symptoms in methamphetamine-induced psychosis compared to schizophrenia: A systematic review and meta-analysis. Schizophrenia research [Internet]. 2024 May 1;267:182\u201390. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38554698\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38554698\/<\/a><\/p><p>J Martinez-Raga, M Bajouco, D Kenzin, J Sahlsten, D De Berardis, G Tzeferakos, et al. Dual disorder: does expert clinical experience support the rationale for cariprazine use? PubMed [Internet]. 2024 Mar 1 [cited 2025 Jul 12];28(5):2095\u2013106. Available from: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38497891\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38497891\/<\/a><\/p><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Chapter 6 Stimulant use in schizophrenia This chapter explains how psychostimulants affect the brain and body, and how to recognize the signs of stimulant use disorder, intoxication, and withdrawal among people with schizophrenia. It also discusses the challenges and possibilities in managing these dual disorders effectively. Download the chapter Fast Facts Stimulants supercharge the brain. [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-sod.php","meta":{"_acf_changed":false,"rea_page_title_signed_in_meta_block_field":"","rea_page_title_signed_out_meta_block_field":"","rea_page_description_signed_in_meta_block_field":"","rea_page_description_signed_out_meta_block_field":"","rea_page_footer_id_meta_block_field":"","rea_page_footer_date_meta_block_field":"","footnotes":""},"class_list":["post-5727","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages\/5727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/comments?post=5727"}],"version-history":[{"count":0,"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/pages\/5727\/revisions"}],"wp:attachment":[{"href":"https:\/\/schizophrenia.life\/public\/wp-json\/wp\/v2\/media?parent=5727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}