Acute patients are schizophrenia patients who are markedly or severely ill (PANSS total score ≥ 80 and ≤ 120) and are experiencing either their first episode of psychosis or a psychotic relapse.
Negative symptoms refer to a loss of patient functioning, constituted by 5 constructs, known as the 5As: alogia, blunted affect, anhedonia, avolition, and asociality.
Subacute schizophrenia patients are subjects who transitioned from the acute to the subacute phase due to symptom remission (PANSS total score range is 50-75; moderately ill). The delusions, hallucinations, disorganised thinking, and/or formal thought disorder that were more prominent in the acute phase may still be present in milder form.
Some schizophrenia patients with therapeutic compromise experience issues with their antipsychotic medication due to either ineffectiveness of the medication itself or non-compliance. These patients usually require a switch in their antipsychotic medication.